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Monday, April 25, 2005

Publishing of the Central Dogma

James D. Watson and Francis Crick's D.N.A. model attracted great interest immediately upon its presentation. Arriving at their conclusion in early 1953, Watson and Crick made their first announcement on at the end of February of that year. Their paper 'A Structure for Deoxyribose Nucleic Acid' was published 52 years ago today. (via

If it is assumed that the bases only occur in the structure in the most plausible tautomeric forms (that is, with the keto rather than the enol configurations) it is found that only specific pairs of bases can bond together. These pairs are : adenine (purine) with thymine (pyrimidine), and guanine (purine) with cytosine (pyrimidine).
Well, duh! You would have to be blind not to see that... How could Linus Pauling be so off the mark?! Pshaw!


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